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产品介绍 宏基因组(metagenome)是指特定环境中全部生物(微生物)遗传物质的总和。宏基因组测序以特定环境中的整个微生物群落作为研究的对象,不需对微生物进行分离培养,而是提取环境微生物总DNA进行研究。其摆脱了传统研究中微生物分离培养的技术限制,在基因组水平解读微生物群体的多样性和丰度,探索微生物与环境及宿主之间的关系。目前,第二代高通量测序技术在宏基因组的研究上已被广泛应用。第二代高通量测序平台具有通量高、准确性高、速度快、信息全等特点,加快了宏基因组测序在鉴定低丰度的微生物群落,挖掘更多基因资源方面的应用。
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项目经验 1. Metagenomic insights into the microbe-mediated B and K2 vitamin biosynthesis in the gastrointestinal microbiome of ruminants. Microbiome (IF=16.837),2022 2. An integrated gene catalog and over 10,000 metagenome-assembled genomes from the gastrointestinal microbiome of ruminants. Microbime (IF=14.65),2021 3. Long-term efect of epigenetic modifcation in plant–microbe interactions: modifcation of DNA methylation induced by plant growth promoting bacteria mediates promotion process. Microbiome (IF=14.65),2022 4. Initial soil microbiome composition and functioning predetermine future plant health. Science Advances (IF=13.293),2019 5. Dietary selection of metabolically distinct microorganisms drives hydrogen metabolism in ruminants. ISME(IF=11.217), 2022 6. Tidal flat aquaculture pollution governs sedimentary antibiotic resistance gene profiles but not bacterial community based on metagenomic data. Science of the Total Environment(IF=10.753), 2022 7. Carboxylesterases from bacterial enrichment culture degrade strobilurin fungicides.Science of the Total Environment(IF=10.753), 2022 8. Para-chloro-meta-xylenol reshaped the fates of antibiotic resistance genes during sludge fermentation: Insights of cell membrane permeability, bacterial structure and biological pathways.Science of the Total Environment(IF=10.753), 2022 9. Metagenomic approach reveals the fates and mechanisms of antibiotic resistance genes exposed to allicins during waste activated sludge fermentation: Insight of the microbial community, cellular status and gene regulation. Bioresour Technol(IF=9.642),2020 10. Effects of persulfate treatment on the fates of antibiotic resistance genes in waste activated sludge fermentation process and the underlying mechanism. Bioresour Technol(IF=9.642),2020
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上海凌恩生物科技有限公司2014年成立于上海,是一家从事生物科研技术服务的高科技公司,专注于二代高通量测序与三代单分子测序服务在科研与人类健康领域的应用和研究。
公司以北京大学、南京大学以及中国科学院等国内外高等院校与科研院所的专家教授作为技术依托,吸纳多名在生物信息高级技术人员的加盟,参与并完成多个高科技 项目。目前的研究成果发表在Nature、Cell、PNAS等国际顶尖学术期刊。随着二代测序的普及和三代测序的方兴未艾,上海凌恩以打造国内一流测序服务与试剂研发服务团队为目标,努力推进我国的基因组学科研与其在人类健康与农业领域的深度应用与发展。